Novel Anticancer Strategies

Novel Strategies for the Discovery of Plant-Derived Anticancer Agents

Work has continued on the investigation of plants, collected mainly from tropical rainforests, as potential sources of new cancer chemotherapeutic agents. About 400 primary samples are obtained each year, with the chloroform-soluble extract of each being screened against a battery of in vitro assays housed at the three consortial sites in our current National Cooperative Drug Discovery Group (N...

Podophyllotoxin: a novel potential natural anticancer agent

Objective: The aim of the present review is to give an overview about the role, biosynthesis, and characteristics of Podophyllotoxin (PTOX) as a potential antitumor agent with particular emphasis on key biosynthesis processes, function of related enzymes and characterization of genes encoding the enzymes. Materials and Methods: Google scholar, PubMed and Scopus were searched for literatures wh...

Customizing anticancer strategies to local needs.

W orldwide, the number of cancer cases each year could reach 27 million by 2030, and more than half of those will most likely occur in lowand middle-income countries, according to the World Health Organization’s World Cancer Report 2008 . Until recently, national cancer control efforts tended to focus on isolated goals: tobacco cessation programs, more radiotherapy machines, or extending the av...

Anticancer metal complexes and tumour targeting strategies

Cytotoxic Peptide Conjugates: Anticancer Therapeutic Strategies

Traditional chemotherapeutic agents exhibit potent anticancer efficacy. However, in clinical applications, they also exhibit severely toxic side effects, and result in multidrug resistance (MDR) of cancer cells. So, receptor-targeted therapy is catching more attention of scientists from both academic and industry and recently is coming to the central stage of drug development. Certain peptides,...